Highly chemoselective metal-free reduction of tertiary amides.
نویسندگان
چکیده
This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.
منابع مشابه
Chemoselective Reduction of Tertiary Amides under Thermal Control: Formation of either Aldehydes or Amines.
The chemoselective reduction of amides in the presence of other more reactive reducible functional groups is a highly challenging transformation, and successful examples thereof are most valuable in synthetic organic chemistry. Only a limited number of systems have demonstrated the chemoselective reduction of amides over ketones. Until now, the aldehyde functionality has not been shown to be co...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 130 1 شماره
صفحات -
تاریخ انتشار 2008